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It was a time of world exploration and Europeans took the disease to Calcutta in 1498, and by 1520 it had reached Africa, the near East, China, Japan and Oceania. Command=Doc Name&File=Osleriana&Name=Internal Medicine as a Vocation , accessed on 6.6.12.
Then they were thrown out and deprived of Naples and Genoa.
In 1934 a new hypothesis was put forward, that syphilis had previously existed in the Old World before Columbus.
I In the 1980’s palaeopathological studies found possible evidence that supported this hypothesis and that syphilis was an old treponeal disease which in the late 15th century had suddenly evolved to become different and more virulent.
In the Vietnam War during the period 1963 to 1970 the overall average annual incidence of STD’s was 262 per 1,000 strength, compared with, at the time, 30 per 1,000 in continental US-based army personnel.
In Vietnam 90% of STD cases were due to gonorrhoea and slightly over 1% were due to syphilis.
The soldiers of Alphonso II were mostly Spanish mercenaries.
Charles’ army led by General Louis II de la Tremoille crushed all resistance from intervening Italian cities and in February 1495 took Naples.They often extended into the mouth and throat, and sometimes early death occurred.It appears from descriptions by scholars and from woodcut drawings at the time that the disease was much more severe than the syphilis of today, with a higher and more rapid mortality and was more easily spread , possibly because it was a new disease and the population had no immunity against it.In August 1495 the Holy Roman Emperor Maximilian I proclaimed that nothing like this disease had been seen before and that it was punishment from God for blasphemy.By 1500 syphilis had reached the Scandinavian countries, Britain, Hungary, Greece, Poland and Russia.[5, 6, 7] During the Battle of Forova at Emilia in Italy on Charles’ retreat back to France, many soldiers were so ill they were unable to fight.